Nature Conference: Advances in Metabolic Communication
The coordination of nutrient sensing and energy metabolism is essential for the maintenance of cellular and organismal homeostasis. To achieve this finely tuned regulation, metabolic information must be communicated among cells, tissues and organs. The goal of this conference is to bring together experts from diverse fields to discuss recent advances in understanding how signaling pathways in one organelle, cell or tissue may influence metabolic functions in other cellular compartments, cells and organs and, ultimately, systemic control of energy homeostasis. The conference will encourage discussion of the physiological processes governing these interactions as well as the role of miscommunication in the development of metabolic diseases and aging. For registration information click here.
Hugo Aguilaniu (Serrapilheira Institute, Brazil), Elena Bellafante (Nature Metabolism, UK), Cristina Caldas (Serrapilheira Institute, Brazil), Fernanda Cunha (Federal University of São Paulo – UNIFESP, Brazil), Julio Ferreira (University of Sao Paulo – USP, Brazil), Christina Kary (Nature Cell Biology, USA), Marcelo Mori (University of Campinas – UNICAMP, Brazil), Christoph Schmitt (Nature Metabolism, Germany).
date15-18 October, 2019
locationBelmond Copacabana Palace
Avenida Atlântica, 1702 - Copacabana, Rio de Janeiro - RJsee map
Ron Kahn harvard medical school, USA
M. Celeste university of pennsylvania, USA
Adam Antebi max planck institute, Germanry
Marcelo Dietrich yale school of medicine, USA
Jens Brüning max planck institute, Germany
Filipe Cabreiro Imperial College London, UK
Dongsheng Cai albert einstein college of medicine, USA
Judith Campisi The Buck Institute for Research on Aging, USA
Ed Chouchani harvard medical school, USA
Ivan de Araujo Mount Sinai, USA
Ana Domingos university of Oxford, UK
Mark Febbraio monash university, Australia
Zach Gerhart-Hines novo nordisk foundation - center for basic metabolic research, Denmark
Eric Verdin The Buck Institute for Research on Aging, USA
Stephan Herzig helmholtz zentrum münchen, Germany
Tiffany Horng ShanghaiTech University, China
Mark Huising university of california, davis, USA
Alicia Kowaltowski university of são paulo, Brazil
Jiandie Lin University of Michigan, USA
Will Mair harvard school of public health, USA
Matthew Potthoff university of iowa, USA
Phil Scherer university of texas southwestern, USA
Amita Sehgal university of pennsylvania, USA
Gerald Shadel salk institute for biological studies, USA
Meng Wang Baylor College of Medicine, USA
Luca Scorrano UNIVERSITY OF PADOVA, ITALY
Fernanda de Felice FEDERAL UNIVERSITY OF RIO DE JANEIRO, BRAZIL
DAY 1 / 14:00 - 22:0014:00-15:00: Registration & Welcome Reception (refreshment/light bites)
Session 1: Communication within cells | Chair: Christoph Schmitt, Nature Metabolism
14:45 - 15:00Welcome remarks and Introduction
15:00 - 15:30Alicia Kowaltowski (University of São Paulo, Brazil) | Diet, mitochondria and calcium: A metabolic triad
15:30 - 16:00Luca Scorrano (University of Padova, Italy) | The mitochondrial cristae shape protein Opa1 promotes adipose tissue browning
16:00 - 16:15Short talk selected from abstracts Mireille Khacho (University of Ottawa, Canada) | Mitochondrial shape changes regulate stem cell fate and regeneration through metabolic communication to the nucleus and extracellular environment
16:15 - 16:30Short talk selected from abstracts Laura Hulea (University of Montreal, Canada) | Acquired resistance to cancer targeted therapy occurs through translational control of metabolism
16:30 - 16:45Short talk selected from abstracts Gustavo Salinas (Pasteur Institute of Montevideo, Uruguay) | Dealing with hypoxia: the alternative electron transport chain of worm mitochondria
16:45 - 17:00Short talk selected from abstracts Olivia Casanueva (Babraham Institute, United Kingdom) | Inter-individual variability in neuronal stress creates phenotypic variability
17:00 - 17:30Coffee Break
17:30 - 18:00Will Mair (Harvard School of Public Health, USA) | Early life spliceosome activity governs efficacy of late-onset longevity interventions
18:00 - 19:00Anibal E. Vercesi Lecture
18:00 - 18:10 Tribute to Prof. Dr. Anibal Vercesi and introduction of keynote speaker
18:10 - 19:10 Celeste Simon (University of Pennsylvania, USA) | Hypoxia, Metabolism, and Tumor Progression
19:10 - 20:30Dinner
19:30 - 22:00Poster Session 1
DAY 2 / 08:00 - 22:00
Session 2: Principles of cell-cell communication | Chair: Christina Kary, Nature Cell Biology
08:00 - 09:00Welcome Coffee
09:00 - 09:30Judith Campisi (The Buck Institute for Research on Aging, USA) | Metabolic signaling during aging through senescent cells
09:30 - 10:00Edward Chouchani (Harvard Medical School, USA) | A quantitative tissue-specific landscape of protein redox regulation during aging
10:00 - 10:30Eric Verdin (The Buck Institute for Research on Aging, USA) | NAD metabolism and chronic inflammation
10:30 - 10:45Short talk selected from abstracts Nalle Pentinmikko (University of Helsinki, Finland) | Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium
10:45 - 11:00Short talk selected from abstracts Eduardo Chini (Mayo Clinic College of Medicine, USA) | Cell to cell compartmentalization of NAD homeostasis in aging and disease
11:00 - 11:30Coffee Break
11:30 - 12:00Amita Sehgal (University of Pennsylvania, USA) | Relevance of metabolic communication for sleep
12:00 - 12:30Ana Domingos (University of Oxford, UK) | Sympathetic neuroimmunity in obesity
12:30 - 13:00Mark Huising (University of California, Davis, USA) | The difference delta cells make: intra-islet crosstalk determines the glycemic set point
13:00 - 16:00Lunch time/ Beach time (Lunch not included)
14:00 - 15:30Workshop: Selection of Abstracts from Young Brazilian Scientists | Chair: Fernanda Cunha, Federal University of São Paulo, Brazil
14:00 - 14:15 Juliano Rodrigues (University of Campinas, Brazil) | Dicer is required for proper circadian rhythmicity of metabolic genes in brown adipose tissue of mice
14:15 - 14:30 Carlos Vergani Jr. (University of Campinas, Brazil) | Dynamic Changes in Argonaute ALG-1 Levels Control miRNA Biogenesis, Alter Stress Response and Affect Healthspan in C. elegans
14:30 - 14:45 Luiz Bechara (University of São Paulo, Brazil) | Mitochondrial formyl peptide attenuates cardiac damage induced by ischemia/reperfusion injury
14:45 - 15:00 Thiago Knittel (University of Campinas, Brazil) | Dicer overexpression is sufficient to promote beige adipogenesis
15:00 - 15:15 Lívia Teixeira (Oswaldo Cruz Institute, Brazil) | Cross-talking between ROS and lipid droplets triggers cellular dysfunction in sepsis
15:15 - 15:30 Narayana Fazolini (University of Campinas, Brazil) | Communication between adipocytes and fibroblasts during senescence: applications to skin aging
Session 3: From organelles to tissues | Chair: Julio Ferreira, University of São Paulo, Brazil
15:30 - 16:00Coffee/ Networking
16:00 - 16:30Gerald Shadel (Salk Institute For Biological Studies, USA) | Mitochondrial Stress Signaling in Disease, Aging and Immunity
16:30 - 17:00Adam Antebi (Max Planck Institute, Germany) | Organellar crosstalk in longevity regulation
17:00 - 17:30Dongsheng Cai (AECM, USA) | Hypothalamus and molecular immunity in metabolic dysregulation
17:30 - 17:45Short talk selected from abstracts Philipp Gut (Nestlé Research, Switzerland) | Succinyl-coa ligase deficiency, a hereditary mitochondrial disease, causes global protein succinylation and metabolic network disruption
17:45 - 18:00Short talk selected from abstracts Babukrishna Maniyadath (Tata Institute of Fundamental Research, India) | Convergent and anticipatory epigenomic mechanisms in the liver regulate whole body energetics and physiological transitions
18:00 - 19:30Dinner
19:30 - 22:00Poster Session 2
DAY 3 / 08:00 - 00:00
Session 4: Inter-organ crosstalk | Chair: Marcelo A. Mori, University of Campinas
08:00 - 09:00Welcome Coffee
09:00 - 09:30Stephan Herzig (Helmholtz Zentrum München, Germany) | Organ cross-talk in cancer and metabolic dysfunction
09:30 - 10:00Jiandie Lin (University of Michigan, USA) | Mapping the landscape of cell-cell communications in metabolic disease
10:00 - 10:30Phil Scherer (University of Texas Southwestern, USA) | The Adipocyte in Systemic Energy Regulation
10:30 - 11:00Coffee Break
11:00 - 11:30Zach Gerhart-Hines (CBMR, Denmark) | Non-canonical signaling pathways controlling adipose thermogenesis
11:30 - 12:00Fernanda de Felice (Federal University of Rio de Janeiro, Brazil) | The influence of periphery-to-brain communication in Alzheimer’s disease
12:00 - 12:15Short talk selected from abstracts Claudio Villanueva (University of California, Los Angeles, USA) | Adipose-Liver Crosstalk and Metabolic Control
12:15 - 12:30Short talk selected from abstracts Luiz O. Leiria (University of Campinas, Brazil) | 12-lipoxygenase regulates cold adaptation and glucose metabolism by producing the omega-3 lipid 12-HEPE from brown fat
12:30 - 15:00Lunch time/ Beach time (Lunch not included)
15:00 - 15:30Coffee/ Networking
15:30 - 16:00Mark Febbraio (Monash University, Australia) | Skeletal muscle secretory proteins: a link between regular physical activity and reduced disease risk in obesity?
16:00 - 16:30Ivan de Araujo (Mount Sinai, USA) | The Gut-Brain Axis and Motivated Behavior
16:30 - 17:00Jens Brüning (Max Planck Institute, Germany) | Heterogenous microarchitecture of melanocortin circuits
17:00 - 19:30Poster session 3
20:00 - 00:00Dinner Party
DAY 4 / 09:00 - 14:00
Session 4: Inter-organ crosstalk | Chair: Elena Bellafante, Nature Metabolism
09:00 - 09:30Matthew Potthoff (University of Iowa, USA) | A liver-brain endocrine axis regulates macronutrient intake
09:30 - 10:00Tiffany Horng (ShanghaiTech University, China) | The glycerol phosphate enzyme GPD2 regulates glucose oxidation and inflammatory responses in macrophages
10:00 - 10:30Meng Wang (Baylor College of Medicine, USA) | Lysosomal Metabolic Signals in Orchestrating Cellular and Organism Homeostasis
10:30 - 11:00Coffee Break
11:00 - 11:30Filipe Cabreiro (Imperial College London, UK) | Drug-Nutrient-Microbe-Host Metabolic Cross-talk to Improve Ageing
11:30 - 12:00Marcelo Dietrich (Yale School of Medicine, USA) | TBD
12:00 - 12:15Short talk selected from abstracts José Donato Jr (University of São Paulo, Brazil) | Central regulation of energy and glucose metabolism by growth hormone
12:15 - 12:30Short talk selected from abstracts Gustavo Menezes (Federal University of Minas Gerais, Brazil) | Immune and metabolic shifts during neonatal development reprogram liver identity and function
12:30 - 13:40Leopoldo de Meis Lecture
12:30 - 12:40: Tribute to Prof. Dr. Leopoldo de Meis and introduction of keynote speaker
12:40 -13:40: Ron Kahn (Harvard Medical School, USA) | Communication by Exosomes Provides Unique Selectivity in Physiological Regulation
13:40 - 14:00Wrap Up and Conclusion
14:30 - 18:30Sugar Loaf Tour (Optional)
registration informationsee below for full details of your experience at the Nature Conference
It is strongly recommended that participants consult http://www.portalconsular.itamaraty.gov.br/vistos as well as the nearest consulate well in advance of their trip to obtain official information on travelling to Brazil.
The entire visa application process is the sole responsibility of each individual traveler.
Who needs a visa to visit Brazil?
Entry visas for visiting Brazil are currently required for citizens from Australia, Canada, Haiti, the United States of America, most countries in Africa, Asia and Oceania, and a few other countries. A complete list of nationalities that need visas is available at http://www.portalconsular.itamaraty.gov.br/images/qgrv/QGRVsimplesing06OUT2017.pdf
Entry visas for Brazil are not required for short tourism and business trips by citizens of most countries in South America, Central America, and Europe, as well as nationals from South Africa, Singapore, Israel, Morocco, Mexico, Mongolia and certain other countries. Citizens from Mercosur countries may enter Brazil with a recent official identification document from their home country in lieu of a passport. Visa-exempt nationalities are subject to other rules regarding allowed activities while in Brazil and maximum periods of stay, which may vary from country to country. Visit the following website for more information: http://www.portalconsular.itamaraty.gov.br/images/qgrv/QGRVsimplesing06OUT2017.pdf
How to apply for a Brazilian visa
If you do need a visa, you must submit a visa application through this website:https://formulario-mre.serpro.gov.br/sci/pages/web/pacomPasesWebInicial.jsf. You will need a passport that is valid for at least six months after your arrival date in Brazil.
Citizens of the United States, Canada, Australia and Japan
Citizens of the United States, Canada, Australia and Japan may now apply for Brazilian visas online, through the eVisa (electronic visa) application website: http://vfsglobal.com/brazil-evisa/
Additional requirements for travelling with minors
Minors under 18 years of age who apply for visas will need an official travel authorization from their parents, legal guardians or other competent authorities. Brazilian hotels will require a similar authorization to host any minor who is not travelling with his or her parents or legal guardians. You should be ready to physically present this authorization (or official copies thereof) upon arrival in the country and at your hotel. Bear in mind that the physical authorization (or its copy) may be retained by the relevant authorities; therefore, you many need to make several copies and have them on hand.
Letter of invitation
If you require a letter of invitation in order to obtain a travel visa, email: email@example.com
Letters will be provided to confirmed registrants.
The official language of Brazil is Portuguese. English and Spanish are usually understood, and sometimes spoken, at airports, travel agencies, and hotels.
Nature provides no insurance coverage and will not accept any responsibility for accidental incidents occurring during the event. Travelers are urged to obtain adequate travel and health insurance before leaving their home countries.
The time zone for Rio de Janeiro is GMT – 3:00.
GIG – Antonio Carlos Jobim International Airport
Hosts domestic and international flights.
Phone: +55 21 3004-6050
GIG is located on an island, “Ilha do Governador”, and connected to the rest of the city by freeways. All Brazilian airlines and over twenty international airlines fly to this airport.
SDU – Santos Dumont Airport
Phone: +55 21 3814-7070
Located in “Centro” (Downtown), SDU connects Rio to the other main cities in Brazil. Buses and VLT trams connect SDU to Downtown and beyond.
There is an express bus from Galeão and Santos Dumont airport to Copacabana, from Premium Company. Route 2018. Fare: R$ 15,00
Taxis and related services
Regular yellow cabs are available all over the city. Additional fees may be charged for transporting large items, such as suitcases above a certain size. Most taxi drivers only accept direct payment in cash. Mobile apps such as Uber, 99 Taxis and EasyTaxi allow users to hail a cab remotely and pay for rides using cash or a pre-registered credit card.
Yellow cabs from Galeão charge an approximate fare of R$ 50-R$60 to Copacabana.
Yellow cabs from Santos Dumont Airport charge an approximate fare of R$ 30-R$40 to Copacabana.
Executive cabs charge an approximate fare of R$ 70-R$80 from Galeão to Copacabana.
Executive cabs charge an approximate fare of R$ 50-R$60 from Santos Dumont to Copacabana.
Taxi rio http://prefeitura.rio/web/taxirio
Car and Van Services
Tel +55-21-3272 5999
Tel +55-21-2269 3312
Rio de Janeiro is a subtropical city at sea level and the Conference will take place during the spring. Typical temperatures may vary between 25 and 42°C (77°-108° F).
Rio’s water is not considered pure by international standards. Due to liberal use of chlorine in the tap water, it is advisable that you only consume bottled or filtered water.
The official currency of Brazil is the real, plural reais (BRL or R$). Coins are available in denominations ranging from 1 real (R$1) to one real cent (R$0,01).
The standard local voltage is 110 – 120 volts. Some buildings (including several hotels) have additional 220-volt power plugs. The current standard is a type N three-pin plug.
A special police department for tourist-related affairs is available. The “Delegacia Especial de Apoio ao Turismo” or DEAT has a specialized team of officers, detectives and administrative staff. English, French, Spanish, German and Italian are spoken.
DEAT – Delegacia Especial de Apoio ao Turismo (Tourist Police)
Address: Rua Humberto de Campos, 315 – Leblon
Phone: +55 21 2334-6804
Credit and debit cards
Visa and MasterCard credit and debit cards are accepted at most restaurants, hotels, banks and shopping malls. American Express and Diners Club are somewhat less popular, but are also accepted in many locations. These cards can also be used to withdraw money from ATMs inside banks such as Banco do Brasil, Bradesco, HSBC, Itaú, and Santander.
Regular business hours
Banks: Monday to Friday, 10am to 4pm.
Offices: Monday to Friday, 9am to 6pm or 8am to 5pm.
Street stores: same as above, with the addition of 9am to 1pm on Saturdays.
Shopping malls: Monday to Saturday, 10am to 10pm; Sunday, 3pm to 9pm.
Restaurants and movie theaters will usually be open for longer hours.
International calls to Rio de Janeiro: The international direct calling code for Brazil is 55, and the local code for Rio is 21. Therefore, when calling a local number from an international phone, add the +55 21 prefix to the number.
Calls from Brazil to other locations: Intermunicipal calls in Brazil require selecting a phone company to route your call. Choose a “prefixo de operadora” (company prefix) from http://www.prefixos.com.br/prefixoddd/operadoras/ and dial as follows:
– for calls to other locations in Brazil,
0 + company prefix + location code + phone number
(E.g.: the company prefix for “Vivo” is 15, location code for São Paulo is 11. To call 2222 3333 in São Paulo from Rio, dial 0 15 11 2222 3333);
– for calls from Brazil to other countries,
00 + company prefix + country code + local code and number
(E.g. the country code for the USA is 1. To call the number 333 4444 in area code 212 using the company “Claro,” dial 00 21 1 212 333 4444.)
Consulates in Rio de Janeiro
You can find a list of consulates here: http://www.rcvb.com.br/consulados
You can use the event booking code for special prices at the hotels bellow.
Booking code: NATURE
Windsor Leme Hotel
Address: Avenida Atlântica, 656 – Leme,
Rio de Janeiro – RJ, 22010-000.
Phone: +55 21 2195-5400
Address: Avenida Atlântica, 1800 – Copacabana,
Rio de Janeiro – RJ, 22021-001.
Phone: +55 21 2195-5800
Address: Avenida Nossa Senhora de Copacabana, 335 – Copacabana,
Rio de Janeiro – RJ, 2020-002.
Phone: +55 21 2195-5300
* The registration will be charged at the exchange rate at the time of payment. According approximately prices are USD and may vary with the exchange rate of the day.
*The registration fee does not include accommodations, which must be booked separately.
Early Registration (Deadline August 23rd)
Students BRL R$ 1.100,00 / $ 275 USD *
Academic BRL R$ 1.760,00 / $ 440 USD *
Industry BRL R$ 2.640,00 / $ 660 USD *
Early Registration with Sugar Loaf Tour on October 18th (Deadline August 23rd)
Students BRL R$ 1.245,20 / $ 312 USD *
Academic BRL R$ 1.905,20 / $ 477 USD *
Industry BRL R$ 2785,20 / $ 697 USD *
Regular Registration (Deadline October 1st)
Students BRL R$ 1.540,00 / $ 385 USD *
Academic BRL R$ 2.200,00 / $ 550 USD *
Industry BRL R$ 3.080,00 / $ 770 USD *
Abstracts submission (Deadline August 23rd)
To submit abstracts and posters click here. The abstract final selection will be informed until September 9th.
Scholarship submission (Deadline postponed to July 1st)
Final result: click here
Serrapilheira Institute will offer 10 scholarships for students and postdoctoral fellows to take part in the upcoming Nature Conference: Advances in Metabolic Communication. The institute will prioritize applications from individuals that have limited access to financial support. The scholarship will offer free admittance to the conference. Abstracts submitted for poster/oral presentation will be used as the basis for awarding the scholarships. To apply for the scholarship, submit your abstract and fill the form through the link. The scholarship new deadline is July 1st. Instituto Serrapilheira will announce the awardees until July 15th.
NOTE: Applying for this scholarship does not exempt you from having to submit your abstract and register through the Nature Conference platform following the Conference deadlines (link). We just ask you to wait for the scholarship decision prior to do so.
– Access to all sessions
– Meals and refreshments as indicated on the program
– Program book
About Sugar Loaf
Over a million tourists every year visit the world famous Pão de Açúcar (Sugar Loaf Mountain), which has become an iconic symbol of the city of Rio de Janeiro. Rising up from a small peninsula at the entrance of Guanabara Bay, its name is said to refer to its resemblance to the traditional shape of concentrated refined sugar loaf. Above sea level, the tour offers a 360 degree view of the entire city including Botafogo and Copacabana Beaches, Corcovado and downtown Rio.
Registration cancellation and Refund Policy
Cancellations received on or before September 24th, 2019 will be honored with a refund minus a $100 administration fee. Refunds will be credited to the credit card account used for registration. No refunds will be disbursed for cancellations received after September 24th, 2019.
To submit abstracts and posters click here.
For questions regarding registration, please contact: firstname.lastname@example.org
About Serrapilheira Institute
Created in 2017, Serrapilheira is a non-profit, private institution which promotes science in Brazil. Its main objective is to finance high-quality research with a focus on knowledge production and science outreach initiatives. We allocate resources to support projects in the natural sciences, computer science, and mathematics. An endowment fund of $110 million was set up in 2016.