How do cells communicate stress signals across different tissues?
Science / Life Sciences
How do stressed cells alert others? Previously thought to be limited to the cell experiencing stress, it is now evident that stress signals can be communicated across tissues, activating protective responses throughout the body. This project examines how cells communicate beyond their immediate environment, with a focus on unconventional signals, including changes in membrane lipid composition. Using model organisms such as Caenorhabditis elegans and mice, we will compare stress responses originating in the nervous system with those perceived in different peripheral tissues. By mapping these communication pathways, we aim to deepen our understanding of the body’s integrated stress response and shed light on the mechanisms underlying age-related diseases.
Amount invested
Institutions
- Universidade de São Paulo
