Alexandre Bruni-Cardoso

Life Sciences

Alexandre Bruni-Cardoso is a biologist with a Ph.D. in cell and structural biology from the University of São Paulo (USP). During his doctoral studies he worked in the laboratory of the Cancer Center at Vanderbilt University, USA. Alexandre’s work uncovers one of the most interesting and mysterious processes of cell division: quiescence. This is the ability of cells to cease proliferation and stop dividing even in the presence of nutrients.

When quiescence fails, cell proliferation is uncontrolled. This process is often called cancer. Many scientists believe that regulating quiescence is an important key to fighting cancer.


Cell Quiescence: Unveiling the mechanisms that govern the pause in cellular activity
Science / Life Sciences

Proliferation is a fundamental and highly conserved characteristic of living systems, and in the context of cancer, it becomes a deregulated process. In a healthy organism, most cells cease to proliferate even in the presence of nutrients and mitogens, entering a reversible state of quiescence. This raises several questions: What regulates quiescence? How is it disrupted in cancer? Why are certain organs more prone to tumor development? Evidence suggests that the extracellular matrix, a microenvironment component, plays a crucial role in the cell’s decision to either proliferate or remain quiescent. Utilizing a CRISPR/CAS9 library, we aim to dissect the signaling pathways involved in regulating extracellular matrix-induced quiescence and track the dynamics of quiescence acquisition at the single-cell level. This research could potentially uncover molecular-level insights into how the microenvironment governs proliferation and how the control of quiescence is compromised in cancer.

Amount invested

R$ 100,000.00

Open Calls

Chamada 1
  • Topics
  • câncer
  • Cell quiescence
  • Extracellular matrix
  • Microenvironment
  • Tumor cells