Guilherme Ost

Life Sciences

Guilherme Ost’s work promises to reveal more fundamental complexities of the most mysterious organ in the human body. With the advancement of technology, we can now simultaneously record the activity of tens to thousands of neurons. However, this view still represents only the “tip of the iceberg” of brain functioning. Ost’s project seeks to develop mathematical and computational tools to expand the understanding of inferring and interpreting interactions between neurons when we observe only a tiny part of a vast neural network. With a degree in mathematics from the Pontifical Catholic University of Rio Grande do Sul, he also has a master’s degree in mathematics from the Federal University of Rio Grande do Sul and a doctorate in statistics from the University of São Paulo. He has three postdoctoral periods, two at USP and one at the Université de Cergy-Pontoise, France.


Given records of the simultaneous activity of a set of neurons, how can we infer the interactions between neurons in that set?
Science / Mathematics

Thanks to recent technological advances, recordings of the simultaneous neural activity of tens to thousands of neurons exposed to different external stimuli, such as visual images and sounds, are now abundant. Even though they are numerous, the neurons observed correspond to a tiny portion of the cortex. It’s as if we only see the tip of a huge iceberg. In this context, the project’s objective is to develop a set of mathematical and computational tools that allow us to answer questions such as: How to infer and interpret interactions between neurons, given that we always observe a few neurons embedded in a huge network? How do these interactions change depending on the external stimulus?

Amount invested

Grant Serrapilheira: R$ 150.000,00
Grant Faperj: R$ 698.068,00

Open Calls

Science Call 6