Can we predict where the next pandemic will come from? Recent studies suggest a clear link between the emergence of infectious diseases and landscape structure changes caused by natural resource exploitation and biodiversity loss. Therefore, understanding the ecological and evolutionary mechanisms that regulate parasite-host dynamics and how they are affected by landscape changes is urgent. This study takes an interdisciplinary approach to the problem by integrating ecological, evolutionary, and epidemiological theory with artificial intelligence and complex network theory tools applied to real-world data. This will allow us to model and predict the dynamics of these interactions, identifying scenarios that favor parasite jumps to new hosts, including humans. We aim to contribute to understanding the mechanisms that have led to the increasing emergence of new diseases and epidemics in the Anthropocene.