COVID-19, a new disease caused by the SARS-CoV-2 coronavirus, was first reported in Wuhan, China in December 2019. It quickly spread worldwide, and the World Health Organization declared it a pandemic on March 13, 2020. Preliminary studies suggest that variants of the virus may be circulating in Brazil, but more data is needed. A project led by UFRJ virologist Amílcar Tanuri aims to understand how the immune systems of Brazilian patients respond to SARS-CoV-2 infection by focusing on healthcare workers, who are at high risk of exposure. The research is supported by a partnership between Serrapilheira and the D’Or Institute for Research and Education (IDOR).