Quantum dots (QDs), which are semiconductor nanocrystals, are widely used in optoelectronic devices, sensors, and as fluorescent probes for detecting (bio)molecular species. Copper and silver chalcogenides, classified as type I-VI QDs, are known for their low toxicity and excellent colloidal stability. Under optimal conditions, these QDs have been proposed as generators of localized surface plasmon resonance, paving the way for new applications such as in SEIRAS (surface enhanced infrared absorption spectroscopy). Silver chalcogenide QDs are particularly suited for producing QDs that emit in the near infrared (NIR), making them highly applicable in biological contexts. These properties, which depend on size and surface ligands, can be fine-tuned by optimizing synthetic procedures. Consequently, the pursuit of improved synthesis conditions significantly contributes to the development and application of low-toxicity systems, achieved through simple and environmentally friendly synthetic processes.