The Seed and the Soil: How the primary tumor interacts with the bone marrow to enable metastasis

Science / Computer Science

Cancer metastasis, the process by which cancer cells spread to other parts of the body, is responsible for more than 90% of cancer deaths. The mechanisms of metastasis are still poorly understood. Cancer cells can spread to the bone marrow, where they can remain dormant and evade the immune system and cancer treatments. Furthermore, for reasons that are not fully understood, these dormant cancer cells can reactivate and lead to the reappearance of the tumor, sometimes in multiple organs, even years after the successful treatment of the primary tumor. Our main goal is to improve our understanding of this process, advance the fundamental understanding of the biology of metastasis, and identify new vulnerabilities of metastatic tumor cells or their tissue microenvironments, which could lead to the development of new therapies.

Amount invested

2022 Grant: R$ 389,180.00

Open Calls

Chamada 5
  • Topics
  • câncer
  • metastasis